مقایسه تأثیر تیوپنتال و پروپوفول بر فشار داخل چشمی طی القاء بیهوشی

 ABSTRACT The prevention of intraocular presure (IOP) has an outstanding effect upon successful ophtalmic surgery. Some stages of induction of anesthesia, like laryngoscopy and endotracheal intubation, cause the IOP increase which has dangreous consequences in open eye injuries. The purpouse of this study is the comparison of IOP changes during the induction of anesthesia using thiopental and propofol under equal conditions to carefully examime the effect of them on the IOP to choose more effective drug in decreasing IOP and prevention of an increase in the IOP following laryngoscopy and intubation. Ninty patients randomly selected to receive either thiopental 4 mg/kg (Group 1) or propofol 2.5 mg/kg (Group 2) for the induction of anesthesia. Both groups received sufentanil 0.15 μg/kg before the induction and atracuium 0.7 mg/kg after the induction of anesthesia. The IOP was measured four times: at preinductional stage, postinductional stage, during laryngoscopy, and 15 seconds after successful intubation. Both groups had a significant decreace in the IOP following the induction of anesthesia (p<0.01). Decresae in the IOP in Group 2 was significantly more than decrease in the IOP in Group 1 (p<0.01) Laryngoscopy and endotracheal intubation cause a significant increase in IOP in Group 1 but not in Group 2 (p<0.01). The IOP in Group 1 had already begun to decline by 15s postintubation. The IOP in both groups never decreased above the baseline during the entire study period. Our conclusion was that propofol caused further decrease in IOP and prevented the IOP increase following laryngoscopy and intubation effectively compared with thiopental.